Osteoarthritis susceptibility genes continue trickling in
نویسندگان
چکیده
منابع مشابه
Linkage analysis of candidate genes as susceptibility loci for osteoarthritis-suggestive linkage of COL9A1 to female hip osteoarthritis.
OBJECTIVE To examine 11 candidate genes as susceptibility loci for osteoarthritis (OA). METHODS A total of 481 families have been ascertained in which at least two siblings have had joint replacement surgery of the hip, or knee, or hip and knee for idiopathic OA. Each candidate gene was targeted using one or more intragenic or closely linked microsatellite marker. The linkage data were analys...
متن کاملOxygen Transfer in Trickling Filters
Insufficient oxygen transfer can result in anaerobic biofilms and odor generation during biochemical oxygen demand (BOD) removal in trickling filters, and can limit ammonia oxidation in nitrifying trickling filters. Since oxygen transfer to biofilms in plastic media trickling filters occurs by diffusion of oxygen through thin fluid films, previous models used solutions based on penetration theo...
متن کاملSusceptibility Genes in Thyroid Autoimmunity
The autoimmune thyroid diseases (AITD) are complex diseases which are caused by an interaction between susceptibility genes and environmental triggers. Genetic susceptibility in combination with external factors (e.g. dietary iodine) is believed to initiate the autoimmune response to thyroid antigens. Abundant epidemiological data, including family and twin studies, point to a strong genetic in...
متن کاملEnhanced nitrogen removal in trickling filter plants.
The Beaudesert Sewage Treatment Plant (STP), originally built in 1966 and augmented in 1977, is a typical biological trickling filter (TF) STP comprising primary sedimentation tanks (PSTs), TFs and humus tanks. The plant, despite not originally being designed for nitrogen removal, has been consistently achieving over 60% total nitrogen reduction and low effluent ammonium concentration of less t...
متن کاملTumor Susceptibility Genes.
Cancer develops and progresses as the result of accumulated genetic damage or mutations. These mutations are most commonly described as either oncogenes, which positively regulate cell growth, or tumor suppressor genes, which negatively regulate cell growth. When oncogenes are mutated, cell growth signals are enhanced; mutations in tumor suppressor genes lead to a reduction in the level of grow...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Lancet
سال: 2012
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(12)60818-6